其他名称： RUFY1; RABIP4; ZFYVE12; RUN and FYVE domain-containing protein 1; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
实测条带： 80kD
信号通路： Endocytosis;
功能： domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RUN domain.,subunit:Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.,tissue specificity:Broadly expressed, with highest levels in lung, testis, kidney and brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Early endosome membrane; Peripheral membrane protein.
组织表达： Broadly expressed, with highest levels in lung, testis, kidney and brain.
其他名称： RUFY1; RABIP4; ZFYVE12; RUN and FYVE domain-containing protein 1; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
实测条带： 80kD
信号通路： Endocytosis;
功能： domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RUN domain.,subunit:Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.,tissue specificity:Broadly expressed, with highest levels in lung, testis, kidney and brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Early endosome membrane; Peripheral membrane protein.
组织表达： Broadly expressed, with highest levels in lung, testis, kidney and brain.
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