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RhoGEF p115 Polyclonal Antibody
商品货号: PLA017925
适 应 性: 人,小鼠,大鼠
WB IHC ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: ARHGEF1
  • 蛋白名称: Rho guanine nucleotide exchange factor 1
  • Human_gene_id: 9138
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9138
  • Human_swiss_prot_no: Q92888
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q92888/entry
  • Mouse_gene_id: 16801
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16801
  • Mouse_swiss_prot_no: Q61210
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q61210
  • Rat_swiss_prot_no: Q9Z1I6
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9Z1I6
  • 特异性: RhoGEF p115 Polyclonal Antibody detects endogenous levels of RhoGEF p115 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: ARHGEF1; Rho guanine nucleotide exchange factor 1; 115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
  • 实测条带: 105kD
  • 信号通路: Regulation of Actin Dynamics; AMPK
  • 功能: domain:The DH domain is involved in interaction with CCPG1.,domain:The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.,function:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12.,PTM:Phosphorylated by PKCA.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 RGSL (RGS-like) domain.,subcellular location:Translocated to the membrane by activated GNA13 or LPA stimulation.,subunit:Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1.,tissue specificity:Ubiquitously expressed.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Membrane . Translocated to the membrane by activated GNA13 or LPA stimulation.
  • 组织表达: Ubiquitously expressed.
  • 科研货号: PLA017925
RhoGEF p115 Polyclonal Antibody
Catalog No PLA017925
Product information
  • 基因名称: ARHGEF1
  • 蛋白名称: Rho guanine nucleotide exchange factor 1
  • Human_gene_id: 9138
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9138
  • Human_swiss_prot_no: Q92888
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q92888/entry
  • Mouse_gene_id: 16801
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16801
  • Mouse_swiss_prot_no: Q61210
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q61210
  • Rat_swiss_prot_no: Q9Z1I6
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9Z1I6
  • 特异性: RhoGEF p115 Polyclonal Antibody detects endogenous levels of RhoGEF p115 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: ARHGEF1; Rho guanine nucleotide exchange factor 1; 115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
  • 实测条带: 105kD
  • 信号通路: Regulation of Actin Dynamics; AMPK
  • 功能: domain:The DH domain is involved in interaction with CCPG1.,domain:The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.,function:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12.,PTM:Phosphorylated by PKCA.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 RGSL (RGS-like) domain.,subcellular location:Translocated to the membrane by activated GNA13 or LPA stimulation.,subunit:Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1.,tissue specificity:Ubiquitously expressed.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Membrane . Translocated to the membrane by activated GNA13 or LPA stimulation.
  • 组织表达: Ubiquitously expressed.
  • 科研货号: PLA017925
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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