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Rho B Polyclonal Antibody
商品货号: PLA017916
适 应 性: 人,小鼠,大鼠
WB IHC ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: RHOB
  • 蛋白名称: Rho-related GTP-binding protein RhoB
  • Human_gene_id: 388
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388
  • Human_swiss_prot_no: P62745
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P62745/entry
  • Mouse_gene_id: 11852
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11852
  • Mouse_swiss_prot_no: P62746
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P62746
  • Rat_gene_id: 64373
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64373
  • Rat_swiss_prot_no: P62747
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P62747
  • 特异性: Rho B Polyclonal Antibody detects endogenous levels of Rho B protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: RHOB; ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6
  • 实测条带: 22kD
  • 功能: function:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.,miscellaneous:RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.,PTM:Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.,subunit:Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
  • 组织表达: Aorta,Brain,Fetal brain cortex,Hippocampus,
  • 科研货号: PLA017916
Rho B Polyclonal Antibody
Catalog No PLA017916
Product information
  • 基因名称: RHOB
  • 蛋白名称: Rho-related GTP-binding protein RhoB
  • Human_gene_id: 388
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388
  • Human_swiss_prot_no: P62745
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P62745/entry
  • Mouse_gene_id: 11852
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11852
  • Mouse_swiss_prot_no: P62746
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P62746
  • Rat_gene_id: 64373
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64373
  • Rat_swiss_prot_no: P62747
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P62747
  • 特异性: Rho B Polyclonal Antibody detects endogenous levels of Rho B protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: RHOB; ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6
  • 实测条带: 22kD
  • 功能: function:Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.,miscellaneous:RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.,PTM:Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.,subunit:Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
  • 组织表达: Aorta,Brain,Fetal brain cortex,Hippocampus,
  • 科研货号: PLA017916
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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