功能： function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.,induction:By mitogens.,mass spectrometry: PubMed:1380064,mass spectrometry: PubMed:15923218,mass spectrometry:O-glycosylated PubMed:1380064,online information:RANTES entry,polymorphism:The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3.,PTM:N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.,PTM:The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:T-cell and macrophage specific.,
相关产品： YT4002,KE1058,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted.
组织表达： Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
功能： function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.,induction:By mitogens.,mass spectrometry: PubMed:1380064,mass spectrometry: PubMed:15923218,mass spectrometry:O-glycosylated PubMed:1380064,online information:RANTES entry,polymorphism:The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3.,PTM:N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.,PTM:The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:T-cell and macrophage specific.,
相关产品： YT4002,KE1058,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted.
组织表达： Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
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