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Rad51 Polyclonal Antibody
商品货号: PLA017827
适 应 性: 人,小鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: RAD51
  • 蛋白名称: DNA repair protein RAD51 homolog 1
  • Human_gene_id: 5888
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5888
  • Human_swiss_prot_no: Q06609
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q06609/entry
  • Mouse_gene_id: 19361
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19361
  • Mouse_swiss_prot_no: Q08297
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q08297
  • 特异性: Rad51 Polyclonal Antibody detects endogenous levels of Rad51 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: RAD51; RAD51A; RECA; DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A
  • 实测条带: 42kD
  • 信号通路: Homologous recombination;Pathways in cancer;Pancreatic cancer;
  • 功能: disease:Defects in RAD51 are associated with breast cancer (BC) [MIM:114480].,function:May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments.,PTM:Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination.,similarity:Belongs to the recA family.,similarity:Belongs to the recA family. RAD51 subfamily.,similarity:Contains 1 HhH domain.,subcellular location:Colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage.,subunit:Interacts with BRCA1, BRCA2 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1/CHK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with OBFC2B.,tissue specificity:Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.,
  • 相关产品: YT3965,YT3964,YP1106,YP0376,KA4261C,KA1506C
  • 细胞定位: Nucleus . Cytoplasm . Cytoplasm, perinuclear region. Mitochondrion matrix . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). .
  • 组织表达: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
  • tag: hot
  • 科研货号: PLA017827
Rad51 Polyclonal Antibody
Catalog No PLA017827
Product information
  • 基因名称: RAD51
  • 蛋白名称: DNA repair protein RAD51 homolog 1
  • Human_gene_id: 5888
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5888
  • Human_swiss_prot_no: Q06609
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q06609/entry
  • Mouse_gene_id: 19361
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19361
  • Mouse_swiss_prot_no: Q08297
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q08297
  • 特异性: Rad51 Polyclonal Antibody detects endogenous levels of Rad51 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: RAD51; RAD51A; RECA; DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A
  • 实测条带: 42kD
  • 信号通路: Homologous recombination;Pathways in cancer;Pancreatic cancer;
  • 功能: disease:Defects in RAD51 are associated with breast cancer (BC) [MIM:114480].,function:May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments.,PTM:Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination.,similarity:Belongs to the recA family.,similarity:Belongs to the recA family. RAD51 subfamily.,similarity:Contains 1 HhH domain.,subcellular location:Colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage.,subunit:Interacts with BRCA1, BRCA2 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1/CHK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with OBFC2B.,tissue specificity:Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.,
  • 相关产品: YT3965,YT3964,YP1106,YP0376,KA4261C,KA1506C
  • 细胞定位: Nucleus . Cytoplasm . Cytoplasm, perinuclear region. Mitochondrion matrix . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). .
  • 组织表达: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
  • tag: hot
  • 科研货号: PLA017827
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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