Rac1/2/3/CDC42 Polyclonal Antibody

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商品货号： PLA017818

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： RAC3
蛋白名称： Ras-related C3 botulinum toxin substrate 3
Human_gene_id： 5879/5880/5881/998
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5879
Human_swiss_prot_no： P63000/P15153/P60763/P60953
Human_swiss_link： http://www.uniprot.org/uniprotkb/P63000/entry
Mouse_gene_id： 19353/19354/170758/12540
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19353
Rat_gene_id： 363875/64465
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363875
Rat_swiss_prot_no： Q6RUV5/Q8CFN2
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6RUV5
特异性： Rac1/2/3/CDC42 Polyclonal Antibody detects endogenous levels of Rac1/2/3/CDC42 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： RAC1; TC25; MIG5; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1; RAC2; Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2; RAC3; Ras-related C3 bot
实测条带： 26kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Chemokine;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Toll_Like;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Regulates Actin and Cytoskeleton;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Viral myocarditis;
功能： domain:The effector region mediates interaction with DEF6.,enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.,function:Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.,function:Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with NISCH.,tissue specificity:Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cytoplasm . Cell projection, lamellipodium . Cell projection, dendrite . Cell junction, synapse . Nucleus . Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (PubMed:12551911). .
组织表达： Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
科研货号： PLA017818

Rac1/2/3/CDC42 Polyclonal Antibody

Catalog No PLA017818

Product information

基因名称： RAC3
蛋白名称： Ras-related C3 botulinum toxin substrate 3
Human_gene_id： 5879/5880/5881/998
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5879
Human_swiss_prot_no： P63000/P15153/P60763/P60953
Human_swiss_link： http://www.uniprot.org/uniprotkb/P63000/entry
Mouse_gene_id： 19353/19354/170758/12540
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19353
Rat_gene_id： 363875/64465
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363875
Rat_swiss_prot_no： Q6RUV5/Q8CFN2
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6RUV5
特异性： Rac1/2/3/CDC42 Polyclonal Antibody detects endogenous levels of Rac1/2/3/CDC42 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： RAC1; TC25; MIG5; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1; RAC2; Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2; RAC3; Ras-related C3 bot
实测条带： 26kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Chemokine;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Toll_Like;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Regulates Actin and Cytoskeleton;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Viral myocarditis;
功能： domain:The effector region mediates interaction with DEF6.,enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.,function:Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.,function:Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with NISCH.,tissue specificity:Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cytoplasm . Cell projection, lamellipodium . Cell projection, dendrite . Cell junction, synapse . Nucleus . Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (PubMed:12551911). .
组织表达： Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
科研货号： PLA017818

Hunan UPT Biotechnology Co.,Ltd

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