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PTP IA-2β Polyclonal Antibody
商品货号: PLA017768
适 应 性: 人,小鼠,大鼠
WB IHC ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PTPRN2
  • 蛋白名称: Receptor-type tyrosine-protein phosphatase N2
  • Human_gene_id: 5799
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5799
  • Human_swiss_prot_no: Q92932
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q92932/entry
  • Mouse_gene_id: 19276
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19276
  • Mouse_swiss_prot_no: P80560
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P80560
  • Rat_gene_id: 29714
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29714
  • Rat_swiss_prot_no: Q63475
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q63475
  • 特异性: PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin
  • 实测条带: 111kD
  • 信号通路: Type I diabetes mellitus;
  • 功能: catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM).,domain:The cytoplasmic domain appears to contain the autoantigenic epitopes.,function:Implicated in development of nervous system and pancreatic endocrine cells.,PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). .; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane .
  • 组织表达: Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755).
  • 科研货号: PLA017768
PTP IA-2β Polyclonal Antibody
Catalog No PLA017768
Product information
  • 基因名称: PTPRN2
  • 蛋白名称: Receptor-type tyrosine-protein phosphatase N2
  • Human_gene_id: 5799
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5799
  • Human_swiss_prot_no: Q92932
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q92932/entry
  • Mouse_gene_id: 19276
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19276
  • Mouse_swiss_prot_no: P80560
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P80560
  • Rat_gene_id: 29714
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29714
  • Rat_swiss_prot_no: Q63475
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q63475
  • 特异性: PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin
  • 实测条带: 111kD
  • 信号通路: Type I diabetes mellitus;
  • 功能: catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM).,domain:The cytoplasmic domain appears to contain the autoantigenic epitopes.,function:Implicated in development of nervous system and pancreatic endocrine cells.,PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). .; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane .
  • 组织表达: Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755).
  • 科研货号: PLA017768
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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