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PP2A-B55-β Polyclonal Antibody
商品货号: PLA017706
适 应 性: 人,小鼠,大鼠
WB IHC
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: PPP2R2B
  • 蛋白名称: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
  • Human_gene_id: 5521
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5521
  • Human_swiss_prot_no: Q00005
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q00005/entry
  • Mouse_gene_id: 72930
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72930
  • Mouse_swiss_prot_no: Q6ZWR4
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q6ZWR4
  • Rat_gene_id: 60660
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60660
  • Rat_swiss_prot_no: P36877
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P36877
  • 特异性: PP2A-B55-β Polyclonal Antibody detects endogenous levels of PP2A-B55-β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PPP2R2B; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
  • 实测条带: 51kD
  • 信号通路: Akt_PKB;Tight junction;
  • 功能: disease:Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).,function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,similarity:Belongs to the phosphatase 2A regulatory subunit B family.,similarity:Contains 7 WD repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.,tissue specificity:Brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: [Isoform 1]: Cytoplasm . Cytoplasm, cytoskeleton . Membrane .; [Isoform 2]: Cytoplasm . Mitochondrion . Mitochondrion outer membrane . Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). .
  • 组织表达: Brain.
  • 科研货号: PLA017706
PP2A-B55-β Polyclonal Antibody
Catalog No PLA017706
Product information
  • 基因名称: PPP2R2B
  • 蛋白名称: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
  • Human_gene_id: 5521
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5521
  • Human_swiss_prot_no: Q00005
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q00005/entry
  • Mouse_gene_id: 72930
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72930
  • Mouse_swiss_prot_no: Q6ZWR4
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q6ZWR4
  • Rat_gene_id: 60660
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60660
  • Rat_swiss_prot_no: P36877
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P36877
  • 特异性: PP2A-B55-β Polyclonal Antibody detects endogenous levels of PP2A-B55-β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PPP2R2B; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
  • 实测条带: 51kD
  • 信号通路: Akt_PKB;Tight junction;
  • 功能: disease:Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).,function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,similarity:Belongs to the phosphatase 2A regulatory subunit B family.,similarity:Contains 7 WD repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.,tissue specificity:Brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: [Isoform 1]: Cytoplasm . Cytoplasm, cytoskeleton . Membrane .; [Isoform 2]: Cytoplasm . Mitochondrion . Mitochondrion outer membrane . Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). .
  • 组织表达: Brain.
  • 科研货号: PLA017706
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
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