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POT1 Polyclonal Antibody
商品货号: PLA017699
适 应 性: 人,猴
WB IHC
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: POT1
  • 蛋白名称: Protection of telomeres protein 1
  • Human_gene_id: 25913
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25913
  • Human_swiss_prot_no: Q9NUX5
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q9NUX5/entry
  • Mouse_swiss_prot_no: Q91WC1
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q91WC1
  • 特异性: POT1 Polyclonal Antibody detects endogenous levels of POT1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
  • 实测条带: 70kD
  • 功能: alternative products:A number of isoforms are produced,function:Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity.,similarity:Belongs to the telombin family.,subcellular location:Colocalizes with telomeric DNA.,subunit:Homodimer or homooligomer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer (By similarity). Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD.,tissue specificity:Ubiquitous.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA.
  • 组织表达: Ubiquitous.
  • 科研货号: PLA017699
POT1 Polyclonal Antibody
Catalog No PLA017699
Product information
  • 基因名称: POT1
  • 蛋白名称: Protection of telomeres protein 1
  • Human_gene_id: 25913
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25913
  • Human_swiss_prot_no: Q9NUX5
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q9NUX5/entry
  • Mouse_swiss_prot_no: Q91WC1
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q91WC1
  • 特异性: POT1 Polyclonal Antibody detects endogenous levels of POT1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
  • 实测条带: 70kD
  • 功能: alternative products:A number of isoforms are produced,function:Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity.,similarity:Belongs to the telombin family.,subcellular location:Colocalizes with telomeric DNA.,subunit:Homodimer or homooligomer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer (By similarity). Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD.,tissue specificity:Ubiquitous.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA.
  • 组织表达: Ubiquitous.
  • 科研货号: PLA017699
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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