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PLC γ1 Polyclonal Antibody
商品货号: PLA017673
适 应 性: 人,小鼠,大鼠,猴
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PLCG1
  • 蛋白名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  • Human_gene_id: 5335
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5335
  • Human_swiss_prot_no: P19174
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P19174/entry
  • Mouse_gene_id: 18803
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18803
  • Mouse_swiss_prot_no: Q62077
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q62077
  • Rat_gene_id: 25738
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25738
  • Rat_swiss_prot_no: P10686
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P10686
  • 特异性: PLC γ1 Polyclonal Antibody detects endogenous levels of PLC γ1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PLCG1; PLC1; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
  • 实测条带: 150kD
  • 信号通路: Inositol phosphate metabolism;ErbB_HER;Calcium;Phosphatidylinositol signaling system;VEGF;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Glioma;Non-small cell lung cancer;
  • 功能: catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,domain:The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.,function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.,PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors.,PTM:Ubiquitinated by CBLB in activated T-cells.,similarity:Contains 1 C2 domain.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH2 domains.,similarity:Contains 3 PH domains.,subunit:Interacts with AGAP2 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and CLNK (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.,
  • 相关产品: YT3793,YT3792,YT3791,YP0607,YP0315,YP0234,KA3167C,KA1323C,KA1214C,KA1213C
  • 细胞定位: Cell projection, lamellipodium . Cell projection, ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .
  • 组织表达: Brain,Epithelium,Testis,Vein,
  • tag: hot
  • 科研货号: PLA017673
PLC γ1 Polyclonal Antibody
Catalog No PLA017673
Product information
  • 基因名称: PLCG1
  • 蛋白名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  • Human_gene_id: 5335
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5335
  • Human_swiss_prot_no: P19174
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P19174/entry
  • Mouse_gene_id: 18803
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18803
  • Mouse_swiss_prot_no: Q62077
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q62077
  • Rat_gene_id: 25738
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25738
  • Rat_swiss_prot_no: P10686
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P10686
  • 特异性: PLC γ1 Polyclonal Antibody detects endogenous levels of PLC γ1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PLCG1; PLC1; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
  • 实测条带: 150kD
  • 信号通路: Inositol phosphate metabolism;ErbB_HER;Calcium;Phosphatidylinositol signaling system;VEGF;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Glioma;Non-small cell lung cancer;
  • 功能: catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,domain:The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.,function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.,PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors.,PTM:Ubiquitinated by CBLB in activated T-cells.,similarity:Contains 1 C2 domain.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH2 domains.,similarity:Contains 3 PH domains.,subunit:Interacts with AGAP2 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and CLNK (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.,
  • 相关产品: YT3793,YT3792,YT3791,YP0607,YP0315,YP0234,KA3167C,KA1323C,KA1214C,KA1213C
  • 细胞定位: Cell projection, lamellipodium . Cell projection, ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .
  • 组织表达: Brain,Epithelium,Testis,Vein,
  • tag: hot
  • 科研货号: PLA017673
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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