Plasminogen Polyclonal Antibody

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商品货号： PLA017669

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PLG
蛋白名称： Plasminogen
Human_gene_id： 5340
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5340
Human_swiss_prot_no： P00747
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00747/entry
Mouse_swiss_prot_no： P20918
Mouse_swiss_link： http://www.uniprot.org/uniprot/P20918
特异性： Plasminogen Polyclonal Antibody detects endogenous levels of Plasminogen protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PLG; Plasminogen
实测条带： 90kD
信号通路： Neuroactive ligand-receptor interaction;Complement and coagulation cascades;
功能： catalytic activity:Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.,disease:Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis.,disease:Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed "ligneous" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract.,domain:Kringle domains mediate interaction with CSPG4.,enzyme regulation:Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.,function:Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.,function:Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.,miscellaneous:Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.,online information:Plasmin entry,PTM:In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.,PTM:N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasminogen subfamily.,similarity:Contains 1 PAN domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 5 kringle domains.,subunit:Interacts with AMOT and CSPG4 (also true for angiostatin).,tissue specificity:Present in plasma and many other extracellular fluids. It is synthesized in the liver.,
相关产品： YT3786,YC0103,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
组织表达： Present in plasma and many other extracellular fluids. It is synthesized in the liver.
科研货号： PLA017669

Plasminogen Polyclonal Antibody

Catalog No PLA017669

Product information

基因名称： PLG
蛋白名称： Plasminogen
Human_gene_id： 5340
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5340
Human_swiss_prot_no： P00747
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00747/entry
Mouse_swiss_prot_no： P20918
Mouse_swiss_link： http://www.uniprot.org/uniprot/P20918
特异性： Plasminogen Polyclonal Antibody detects endogenous levels of Plasminogen protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PLG; Plasminogen
实测条带： 90kD
信号通路： Neuroactive ligand-receptor interaction;Complement and coagulation cascades;
功能： catalytic activity:Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.,disease:Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis.,disease:Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed "ligneous" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract.,domain:Kringle domains mediate interaction with CSPG4.,enzyme regulation:Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.,function:Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.,function:Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.,miscellaneous:Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.,online information:Plasmin entry,PTM:In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.,PTM:N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasminogen subfamily.,similarity:Contains 1 PAN domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 5 kringle domains.,subunit:Interacts with AMOT and CSPG4 (also true for angiostatin).,tissue specificity:Present in plasma and many other extracellular fluids. It is synthesized in the liver.,
相关产品： YT3786,YC0103,RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
组织表达： Present in plasma and many other extracellular fluids. It is synthesized in the liver.
科研货号： PLA017669

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