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PKN Polyclonal Antibody
商品货号: PLA017663
适 应 性: 人,小鼠,大鼠
WB IHC
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PKN1
  • 蛋白名称: Serine/threonine-protein kinase N1
  • Human_gene_id: 5585
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5585
  • Human_swiss_prot_no: Q16512
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q16512/entry
  • Mouse_gene_id: 320795
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320795
  • Mouse_swiss_prot_no: P70268
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P70268
  • Rat_gene_id: 29355
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29355
  • Rat_swiss_prot_no: Q63433
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q63433
  • 特异性: PKN Polyclonal Antibody detects endogenous levels of PKN protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PKN1; PAK1; PKN; PRK1; PRKCL1; Serine/threonine-protein kinase N1; Protease-activated kinase 1; PAK-1; Protein kinase C-like 1; Protein kinase C-like PKN; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; Serine-threonine protein
  • 实测条带: 105kD
  • 信号通路: Akt_PKB
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.,function:Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling.,PTM:Activated by limited proteolysis with trypsin.,PTM:Autophosphorylated; preferably on serine.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,subunit:Interacts with ZA20D3 (By similarity). Interacts with RhoA and Rac1.,tissue specificity:Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.,
  • 相关产品: YT3778,YN0043,RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Nucleus . Endosome . Cell membrane ; Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. .
  • 组织表达: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
  • 科研货号: PLA017663
PKN Polyclonal Antibody
Catalog No PLA017663
Product information
  • 基因名称: PKN1
  • 蛋白名称: Serine/threonine-protein kinase N1
  • Human_gene_id: 5585
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5585
  • Human_swiss_prot_no: Q16512
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q16512/entry
  • Mouse_gene_id: 320795
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320795
  • Mouse_swiss_prot_no: P70268
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P70268
  • Rat_gene_id: 29355
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29355
  • Rat_swiss_prot_no: Q63433
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q63433
  • 特异性: PKN Polyclonal Antibody detects endogenous levels of PKN protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PKN1; PAK1; PKN; PRK1; PRKCL1; Serine/threonine-protein kinase N1; Protease-activated kinase 1; PAK-1; Protein kinase C-like 1; Protein kinase C-like PKN; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; Serine-threonine protein
  • 实测条带: 105kD
  • 信号通路: Akt_PKB
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916 (turn motif), need to be phosphorylated for its full activation.,function:Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling.,PTM:Activated by limited proteolysis with trypsin.,PTM:Autophosphorylated; preferably on serine.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,subunit:Interacts with ZA20D3 (By similarity). Interacts with RhoA and Rac1.,tissue specificity:Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.,
  • 相关产品: YT3778,YN0043,RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Nucleus . Endosome . Cell membrane ; Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. .
  • 组织表达: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells.
  • 科研货号: PLA017663
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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