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PKC θ Polyclonal Antibody
商品货号: PLA017655
适 应 性: 人,小鼠,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PRKCQ
  • 蛋白名称: Protein kinase C theta type
  • Human_gene_id: 5588
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5588
  • Human_swiss_prot_no: Q04759
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q04759/entry
  • Mouse_gene_id: 18761
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18761
  • Mouse_swiss_prot_no: Q02111
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q02111
  • Rat_swiss_prot_no: Q9WTQ0
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9WTQ0
  • 特异性: PKC θ Polyclonal Antibody detects endogenous levels of PKC θ protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta
  • 实测条带: 78kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; NF_kappaB; B Cell Receptor; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.,PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with TXNL2/PICOT.,tissue specificity:Skeletal muscle, megakaryoblastic cells and platelets.,
  • 相关产品: YT3768,YT3767,YT3766,YP0719,YP0705,YP0231,KA4240C,KA1639C,KA1411C,KA1388C
  • 细胞定位: Cytoplasm. Cell membrane; Peripheral membrane protein. In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
  • 组织表达: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.
  • 科研货号: PLA017655
PKC θ Polyclonal Antibody
Catalog No PLA017655
Product information
  • 基因名称: PRKCQ
  • 蛋白名称: Protein kinase C theta type
  • Human_gene_id: 5588
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5588
  • Human_swiss_prot_no: Q04759
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q04759/entry
  • Mouse_gene_id: 18761
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18761
  • Mouse_swiss_prot_no: Q02111
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q02111
  • Rat_swiss_prot_no: Q9WTQ0
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9WTQ0
  • 特异性: PKC θ Polyclonal Antibody detects endogenous levels of PKC θ protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta
  • 实测条带: 78kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; NF_kappaB; B Cell Receptor; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.,PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with TXNL2/PICOT.,tissue specificity:Skeletal muscle, megakaryoblastic cells and platelets.,
  • 相关产品: YT3768,YT3767,YT3766,YP0719,YP0705,YP0231,KA4240C,KA1639C,KA1411C,KA1388C
  • 细胞定位: Cytoplasm. Cell membrane; Peripheral membrane protein. In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
  • 组织表达: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.
  • 科研货号: PLA017655
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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