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PKC ε Polyclonal Antibody
商品货号: PLA017653
适 应 性: 人,小鼠,大鼠
WB IHC ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PRKCE
  • 蛋白名称: Protein kinase C epsilon type
  • Human_gene_id: 5581
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5581
  • Human_swiss_prot_no: Q02156
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q02156/entry
  • Mouse_gene_id: 18754
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18754
  • Mouse_swiss_prot_no: P16054
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P16054
  • Rat_gene_id: 29340
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29340
  • Rat_swiss_prot_no: P09216
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P09216
  • 特异性: PKC ε Polyclonal Antibody detects endogenous levels of PKC ε protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCE; PKCE; Protein kinase C epsilon type; nPKC-epsilon
  • 实测条带: 83kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; B Cell Receptor; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.,PTM:Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Forms a ternary complex with TRIM63 and GN2BL1.,
  • 相关产品: YT3763,YP0340,KA4238C,KA1410C
  • 细胞定位: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cytoplasm, perinuclear region . Nucleus . Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). .
  • 组织表达: Expressed in cumulus cells (at protein level).
  • 科研货号: PLA017653
PKC ε Polyclonal Antibody
Catalog No PLA017653
Product information
  • 基因名称: PRKCE
  • 蛋白名称: Protein kinase C epsilon type
  • Human_gene_id: 5581
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5581
  • Human_swiss_prot_no: Q02156
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/Q02156/entry
  • Mouse_gene_id: 18754
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18754
  • Mouse_swiss_prot_no: P16054
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P16054
  • Rat_gene_id: 29340
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29340
  • Rat_swiss_prot_no: P09216
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P09216
  • 特异性: PKC ε Polyclonal Antibody detects endogenous levels of PKC ε protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCE; PKCE; Protein kinase C epsilon type; nPKC-epsilon
  • 实测条带: 83kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; B Cell Receptor; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.,PTM:Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Forms a ternary complex with TRIM63 and GN2BL1.,
  • 相关产品: YT3763,YP0340,KA4238C,KA1410C
  • 细胞定位: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cytoplasm, perinuclear region . Nucleus . Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). .
  • 组织表达: Expressed in cumulus cells (at protein level).
  • 科研货号: PLA017653
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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