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PKC β Polyclonal Antibody
商品货号: PLA017651
适 应 性: 人,小鼠,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PRKCB
  • 蛋白名称: Protein kinase C beta type
  • Human_gene_id: 5579
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5579
  • Human_swiss_prot_no: P05771
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P05771/entry
  • Mouse_gene_id: 18751
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18751
  • Mouse_swiss_prot_no: P68404
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P68404
  • Rat_gene_id: 25023
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25023
  • Rat_swiss_prot_no: P68403
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P68403
  • 特异性: PKC β Polyclonal Antibody detects endogenous levels of PKC β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCB; PKCB; PRKCB1; Protein kinase C beta type; PKC-B; PKC-beta
  • 实测条带: 77kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; ErbB/HER; MAPK_ERK_Growth;MAPK_G_Protein; WNT;WNT-T CELL;β-Catenin; B Cell Receptor; NF_kappaB; mTOR; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain.,function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking.,PTM:Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.,
  • 相关产品: YT3756,YP0432,KA4241C,KA1717C
  • 细胞定位: Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .
  • 组织表达: Fetal brain,Hippocampus,Platelet,
  • tag: hot
  • 科研货号: PLA017651
PKC β Polyclonal Antibody
Catalog No PLA017651
Product information
  • 基因名称: PRKCB
  • 蛋白名称: Protein kinase C beta type
  • Human_gene_id: 5579
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5579
  • Human_swiss_prot_no: P05771
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P05771/entry
  • Mouse_gene_id: 18751
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18751
  • Mouse_swiss_prot_no: P68404
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P68404
  • Rat_gene_id: 25023
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25023
  • Rat_swiss_prot_no: P68403
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P68403
  • 特异性: PKC β Polyclonal Antibody detects endogenous levels of PKC β protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PRKCB; PKCB; PRKCB1; Protein kinase C beta type; PKC-B; PKC-beta
  • 实测条带: 77kD
  • 信号通路: Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; Insulin Receptor; ErbB/HER; MAPK_ERK_Growth;MAPK_G_Protein; WNT;WNT-T CELL;β-Catenin; B Cell Receptor; NF_kappaB; mTOR; AMPK
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain.,function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking.,PTM:Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly, isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659', subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.,
  • 相关产品: YT3756,YP0432,KA4241C,KA1717C
  • 细胞定位: Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .
  • 组织表达: Fetal brain,Hippocampus,Platelet,
  • tag: hot
  • 科研货号: PLA017651
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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