PKA Iα reg Polyclonal Antibody

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商品货号： PLA017643

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PRKAR1A
蛋白名称： cAMP-dependent protein kinase type I-alpha regulatory subunit
Human_gene_id： 5573
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5573
Human_swiss_prot_no： P10644
Human_swiss_link： http://www.uniprot.org/uniprotkb/P10644/entry
Mouse_gene_id： 19084
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19084
Mouse_swiss_prot_no： Q9DBC7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9DBC7
Rat_gene_id： 25725
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25725
Rat_swiss_prot_no： P09456
Rat_swiss_link： http://www.uniprot.org/uniprot/P09456
特异性： PKA Iα reg Polyclonal Antibody detects endogenous levels of PKA Iα reg protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PRKAR1A; PKR1; PRKAR1; TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1
实测条带： 43kD
信号通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Insulin_Receptor;
功能： disease:Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.,disease:Defects in PRKAR1A are the cause of intracardiac myxoma [MIM:255960]. Inheritance is autosomal recessive.,disease:Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.,PTM:The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.,similarity:Belongs to the cAMP-dependent kinase regulatory chain family.,similarity:Contains 2 cyclic nucleotide-binding domains.,subunit:The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4.,tissue specificity:Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.,
相关产品： YT3746,KA3535C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane .
组织表达： Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
科研货号： PLA017643

PKA Iα reg Polyclonal Antibody

Catalog No PLA017643

Product information

基因名称： PRKAR1A
蛋白名称： cAMP-dependent protein kinase type I-alpha regulatory subunit
Human_gene_id： 5573
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5573
Human_swiss_prot_no： P10644
Human_swiss_link： http://www.uniprot.org/uniprotkb/P10644/entry
Mouse_gene_id： 19084
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19084
Mouse_swiss_prot_no： Q9DBC7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9DBC7
Rat_gene_id： 25725
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25725
Rat_swiss_prot_no： P09456
Rat_swiss_link： http://www.uniprot.org/uniprot/P09456
特异性： PKA Iα reg Polyclonal Antibody detects endogenous levels of PKA Iα reg protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： PRKAR1A; PKR1; PRKAR1; TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1
实测条带： 43kD
信号通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Insulin_Receptor;
功能： disease:Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.,disease:Defects in PRKAR1A are the cause of intracardiac myxoma [MIM:255960]. Inheritance is autosomal recessive.,disease:Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.,PTM:The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.,similarity:Belongs to the cAMP-dependent kinase regulatory chain family.,similarity:Contains 2 cyclic nucleotide-binding domains.,subunit:The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. PRKAR1A also interacts with RFC2; the complex may be involved in cell survival. Interacts with AKAP4.,tissue specificity:Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.,
相关产品： YT3746,KA3535C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane .
组织表达： Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
科研货号： PLA017643

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