其他名称： PIAS3; E3 SUMO-protein ligase PIAS3; Protein inhibitor of activated STAT protein 3
实测条带： 68kD
信号通路： Ubiquitin mediated proteolysis;Jak_STAT;Pathways in cancer;Small cell lung cancer;
功能： domain:The LXXLL motif is a transcriptional coregulator signature.,function:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.,induction:By dihydrotestosterone in prostate cancer cells.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated.,similarity:Belongs to the PIAS family.,similarity:Contains 1 SAP domain.,similarity:Contains 1 SP-RING-type zinc finger.,subunit:Binds SUMO1 and UBE2I. Interacts with AR, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation (By similarity). Interacts with PLAG1.,tissue specificity:Widely expressed.,
相关产品： YT3718,KA3412C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. .
其他名称： PIAS3; E3 SUMO-protein ligase PIAS3; Protein inhibitor of activated STAT protein 3
实测条带： 68kD
信号通路： Ubiquitin mediated proteolysis;Jak_STAT;Pathways in cancer;Small cell lung cancer;
功能： domain:The LXXLL motif is a transcriptional coregulator signature.,function:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.,induction:By dihydrotestosterone in prostate cancer cells.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated.,similarity:Belongs to the PIAS family.,similarity:Contains 1 SAP domain.,similarity:Contains 1 SP-RING-type zinc finger.,subunit:Binds SUMO1 and UBE2I. Interacts with AR, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation (By similarity). Interacts with PLAG1.,tissue specificity:Widely expressed.,
相关产品： YT3718,KA3412C,RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. .
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