其他名称： PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A
实测条带： 75kD
信号通路： Purine metabolism;
功能： alternative products:Isoforms differ in their N-terminal region,catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 1 zinc ion.,domain:Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.,domain:The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.,enzyme regulation:Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,pathway:Purine metabolism; cGMP degradation; GMP from cGMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subcellular location:Located mostly to soluble cellular fractions.,subunit:Homodimer.,tissue specificity:Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol .
组织表达： Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
科研货号： PLA017539
PDE10A Polyclonal Antibody
Catalog NoPLA017539
Product information
基因名称： PDE10A
蛋白名称： cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
其他名称： PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A
实测条带： 75kD
信号通路： Purine metabolism;
功能： alternative products:Isoforms differ in their N-terminal region,catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 1 zinc ion.,domain:Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.,domain:The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.,enzyme regulation:Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,pathway:Purine metabolism; cGMP degradation; GMP from cGMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subcellular location:Located mostly to soluble cellular fractions.,subunit:Homodimer.,tissue specificity:Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol .
组织表达： Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
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