信号通路: ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.,PTM:Autophosphorylated on serine residues when activated by CDC42/p21.,PTM:Phosphorylated on tyrosine residues upon stimulation of FGFR2.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. Interacts with its substrate ARHGEF2.,tissue specificity:Highest expression in prostate, testis and colon.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .
组织表达: Highest expression in prostate, testis and colon.
信号通路: ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.,PTM:Autophosphorylated on serine residues when activated by CDC42/p21.,PTM:Phosphorylated on tyrosine residues upon stimulation of FGFR2.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. Interacts with its substrate ARHGEF2.,tissue specificity:Highest expression in prostate, testis and colon.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .
组织表达: Highest expression in prostate, testis and colon.