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PAK4/5/6 Polyclonal Antibody
商品货号: PLA017495
适 应 性: 人,小鼠,大鼠
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: PAK4 PAK5 PAK6
  • 蛋白名称: Serine/threonine-protein kinase PAK 4
  • Human_gene_id: 10298
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10298
  • Human_swiss_prot_no: O96013;Q9P286;Q9NQU5
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O96013/entry
  • Mouse_gene_id: 70584
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70584
  • Mouse_swiss_prot_no: Q8BTW9
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q8BTW9
  • 特异性: PAK4/5/6 Polyclonal Antibody detects endogenous levels of PAK4/5/6 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PAK4; KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
  • 实测条带: 80kD
  • 信号通路: ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.,PTM:Autophosphorylated on serine residues when activated by CDC42/p21.,PTM:Phosphorylated on tyrosine residues upon stimulation of FGFR2.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. Interacts with its substrate ARHGEF2.,tissue specificity:Highest expression in prostate, testis and colon.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .
  • 组织表达: Highest expression in prostate, testis and colon.
  • 科研货号: PLA017495
PAK4/5/6 Polyclonal Antibody
Catalog No PLA017495
Product information
  • 基因名称: PAK4 PAK5 PAK6
  • 蛋白名称: Serine/threonine-protein kinase PAK 4
  • Human_gene_id: 10298
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10298
  • Human_swiss_prot_no: O96013;Q9P286;Q9NQU5
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O96013/entry
  • Mouse_gene_id: 70584
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70584
  • Mouse_swiss_prot_no: Q8BTW9
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q8BTW9
  • 特异性: PAK4/5/6 Polyclonal Antibody detects endogenous levels of PAK4/5/6 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: PAK4; KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
  • 实测条带: 80kD
  • 信号通路: ErbB_HER;Axon guidance;Focal adhesion;T_Cell_Receptor;Regulates Actin and Cytoskeleton;Renal cell carcinoma;
  • 功能: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.,PTM:Autophosphorylated on serine residues when activated by CDC42/p21.,PTM:Phosphorylated on tyrosine residues upon stimulation of FGFR2.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. Interacts with its substrate ARHGEF2.,tissue specificity:Highest expression in prostate, testis and colon.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .
  • 组织表达: Highest expression in prostate, testis and colon.
  • 科研货号: PLA017495
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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