基因名称： TNFRSF11B

蛋白名称： Tumor necrosis factor receptor superfamily member 11B

Human_gene_id： 4982

Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4982

Human_swiss_prot_no： O00300

Human_swiss_link： http://www.uniprot.org/uniprotkb/O00300/entry

Mouse_gene_id： 18383

Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18383

Mouse_swiss_prot_no： O08712

Mouse_swiss_link： http://www.uniprot.org/uniprot/O08712

特异性： OPG Polyclonal Antibody detects endogenous levels of OPG protein.

组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源： Polyclonal, Rabbit,IgG

稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度： 1 mg/ml

储存： -15°C to -25°C/1 year(Do not lower than -25°C)

说明书： 1

Msds： MSDS_Antibody.pdf

其他名称： TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin

实测条带： 46kD

信号通路： Cytokine-cytokine receptor interaction;

功能： disease:Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.,function:Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.,induction:Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.,PTM:N-glycosylated. Contains sialic acid residues.,PTM:The N-terminus is blocked.,similarity:Contains 2 death domains.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer.,tissue specificity:Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.,

相关产品： RS0001,RS0002,YM3028,YM3029

细胞定位： Secreted.

组织表达： Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

tag： hot

科研货号： PLA017432

基因名称： TNFRSF11B

蛋白名称： Tumor necrosis factor receptor superfamily member 11B

Human_gene_id： 4982

Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4982

Human_swiss_prot_no： O00300

Human_swiss_link： http://www.uniprot.org/uniprotkb/O00300/entry

Mouse_gene_id： 18383

Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18383

Mouse_swiss_prot_no： O08712

Mouse_swiss_link： http://www.uniprot.org/uniprot/O08712

特异性： OPG Polyclonal Antibody detects endogenous levels of OPG protein.

组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源： Polyclonal, Rabbit,IgG

稀释： WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度： 1 mg/ml

储存： -15°C to -25°C/1 year(Do not lower than -25°C)

说明书： 1

Msds： MSDS_Antibody.pdf

其他名称： TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin

实测条带： 46kD

信号通路： Cytokine-cytokine receptor interaction;

功能： disease:Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.,function:Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.,induction:Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.,PTM:N-glycosylated. Contains sialic acid residues.,PTM:The N-terminus is blocked.,similarity:Contains 2 death domains.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer.,tissue specificity:Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.,

相关产品： RS0001,RS0002,YM3028,YM3029

细胞定位： Secreted.

组织表达： Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

tag： hot

科研货号： PLA017432