功能： function:Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.,induction:By beta and gamma interferons.,similarity:Contains 3 UBA domains.,subcellular location:Predominantly nuclear.,subunit:Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1.,tissue specificity:Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Predominantly nuclear.
组织表达： Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
功能： function:Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.,induction:By beta and gamma interferons.,similarity:Contains 3 UBA domains.,subcellular location:Predominantly nuclear.,subunit:Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1.,tissue specificity:Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Predominantly nuclear.
组织表达： Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
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