Nanog P8 Polyclonal Antibody

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商品货号： PLA016994

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： NANOGP8
蛋白名称： Putative homeobox protein NANOGP8
Human_gene_id： 388112
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388112
Human_swiss_prot_no： Q6NSW7
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6NSW7/entry
特异性： Nanog P8 Polyclonal Antibody detects endogenous levels of Nanog P8 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： NANOGP8; Putative homeobox protein NANOGP8
实测条带： 35kD
功能： developmental stage:Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.,function:May act as a transcription regulator (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,function:Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,miscellaneous:Almost identical to NANOG. There are only one change in the inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8.,miscellaneous:Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.,online information:Nanog entry,similarity:Belongs to the Nanog homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with SMAD1 and SALL4.,tissue specificity:Expressed in osteosarcoma cancer cell line (at protein level) (Probable). Expressed in tumor uterine cervix, breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines.,tissue specificity:Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Embryonic stem cell,Teratocarcinoma,Urinary bladder carcinoma,
科研货号： PLA016994

Nanog P8 Polyclonal Antibody

Catalog No PLA016994

Product information

基因名称： NANOGP8
蛋白名称： Putative homeobox protein NANOGP8
Human_gene_id： 388112
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=388112
Human_swiss_prot_no： Q6NSW7
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q6NSW7/entry
特异性： Nanog P8 Polyclonal Antibody detects endogenous levels of Nanog P8 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： NANOGP8; Putative homeobox protein NANOGP8
实测条带： 35kD
功能： developmental stage:Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.,function:May act as a transcription regulator (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,function:Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,miscellaneous:Almost identical to NANOG. There are only one change in the inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8.,miscellaneous:Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.,online information:Nanog entry,similarity:Belongs to the Nanog homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with SMAD1 and SALL4.,tissue specificity:Expressed in osteosarcoma cancer cell line (at protein level) (Probable). Expressed in tumor uterine cervix, breast and urinary bladder tissues, and also osteosarcoma, hepatoma, and breast adenocarcinoma cancer cell lines.,tissue specificity:Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Embryonic stem cell,Teratocarcinoma,Urinary bladder carcinoma,
科研货号： PLA016994

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