Na+ CP type IIα Polyclonal Antibody

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商品货号： PLA016984

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： SCN2A
蛋白名称： Sodium channel protein type 2 subunit alpha
Human_gene_id： 6326
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6326
Human_swiss_prot_no： Q99250
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99250/entry
Rat_gene_id： 24766
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24766
Rat_swiss_prot_no： P04775
Rat_swiss_link： http://www.uniprot.org/uniprot/P04775
特异性： Na+ CP type IIα Polyclonal Antibody detects endogenous levels of Na+ CP type IIα protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SCN2A; NAC2; SCN2A1; SCN2A2; Sodium channel protein type 2 subunit alpha; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2
分子量： 228kD
功能： disease:Defects in SCN2A are a cause of generalized epilepsy with febrile seizures plus (GEFS+) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.,disease:Defects in SCN2A are the cause of benign familial infantile convulsions type 3 (BFIC3) [MIM:607745]. BFIC3 is an autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae.,domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,PTM:May be ubiquitinated by NEDD4L; which would promote its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subunit:The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein .
组织表达： Brain,
科研货号： PLA016984

Na+ CP type IIα Polyclonal Antibody

Catalog No PLA016984

Product information

基因名称： SCN2A
蛋白名称： Sodium channel protein type 2 subunit alpha
Human_gene_id： 6326
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6326
Human_swiss_prot_no： Q99250
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99250/entry
Rat_gene_id： 24766
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24766
Rat_swiss_prot_no： P04775
Rat_swiss_link： http://www.uniprot.org/uniprot/P04775
特异性： Na+ CP type IIα Polyclonal Antibody detects endogenous levels of Na+ CP type IIα protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： SCN2A; NAC2; SCN2A1; SCN2A2; Sodium channel protein type 2 subunit alpha; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2
分子量： 228kD
功能： disease:Defects in SCN2A are a cause of generalized epilepsy with febrile seizures plus (GEFS+) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.,disease:Defects in SCN2A are the cause of benign familial infantile convulsions type 3 (BFIC3) [MIM:607745]. BFIC3 is an autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae.,domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,PTM:May be ubiquitinated by NEDD4L; which would promote its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subunit:The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein .
组织表达： Brain,
科研货号： PLA016984

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