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MMP-16 Polyclonal Antibody
商品货号: PLA016946
适 应 性: 人,小鼠,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: MMP16
  • 蛋白名称: Matrix metalloproteinase-16
  • Human_gene_id: 4325
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4325
  • Human_swiss_prot_no: P51512
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P51512/entry
  • Mouse_gene_id: 17389
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17389
  • Mouse_swiss_prot_no: Q9WTR0
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9WTR0
  • Rat_gene_id: 65205
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65205
  • Rat_swiss_prot_no: O35548
  • Rat_swiss_link: http://www.uniprot.org/uniprot/O35548
  • 特异性: MMP-16 Polyclonal Antibody detects endogenous levels of MMP-16 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP16; MMPX2; Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP
  • 实测条带: 70kD
  • 信号通路: Angiogenesis
  • 功能: cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,developmental stage:Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.,function:Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Localized at the cell surface of melanoma cells.,subunit:Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.,tissue specificity:Expressed in heart, brain, placenta, ovary and small intestine. The short isoform is found in the ovary.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: [Isoform Long]: Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.
  • 组织表达: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 科研货号: PLA016946
MMP-16 Polyclonal Antibody
Catalog No PLA016946
Product information
  • 基因名称: MMP16
  • 蛋白名称: Matrix metalloproteinase-16
  • Human_gene_id: 4325
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4325
  • Human_swiss_prot_no: P51512
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P51512/entry
  • Mouse_gene_id: 17389
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17389
  • Mouse_swiss_prot_no: Q9WTR0
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9WTR0
  • Rat_gene_id: 65205
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65205
  • Rat_swiss_prot_no: O35548
  • Rat_swiss_link: http://www.uniprot.org/uniprot/O35548
  • 特异性: MMP-16 Polyclonal Antibody detects endogenous levels of MMP-16 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP16; MMPX2; Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP
  • 实测条带: 70kD
  • 信号通路: Angiogenesis
  • 功能: cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,developmental stage:Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.,function:Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Localized at the cell surface of melanoma cells.,subunit:Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.,tissue specificity:Expressed in heart, brain, placenta, ovary and small intestine. The short isoform is found in the ovary.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: [Isoform Long]: Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.
  • 组织表达: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 科研货号: PLA016946
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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