Microcephalin Polyclonal Antibody

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商品货号： PLA016805

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MCPH1
蛋白名称： Microcephalin
Human_gene_id： 79648
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79648
Human_swiss_prot_no： Q8NEM0
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8NEM0/entry
Mouse_gene_id： 244329
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244329
Mouse_swiss_prot_no： Q7TT79
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q7TT79
特异性： Microcephalin Polyclonal Antibody detects endogenous levels of Microcephalin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MCPH1; Microcephalin
实测条带： 93kD
功能： disease:Defects in MCPH1 are a cause of premature chromosome condensation with microcephaly and mental retardation (PCC syndrome) [MIM:606858]. PCC syndrome is a disorder of microcephaly, short stature and misregulated chromosome condensation. Patients with this condition have a high number (10%-15%) of prophase-like cells in routine cytogenetic preparations and have poor-quality metaphase G-banding.,disease:Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.,function:Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.,miscellaneous:MCPH1 deficient cells exhibit a delay in post-mitotic chromosome decondensation.,online information:A grey matter - Issue 64 of November 2005,similarity:Contains 3 BRCT domains.,tissue specificity:Expressed in fetal brain, liver and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
组织表达： Expressed in fetal brain, liver and kidney.
科研货号： PLA016805

Microcephalin Polyclonal Antibody

Catalog No PLA016805

Product information

基因名称： MCPH1
蛋白名称： Microcephalin
Human_gene_id： 79648
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79648
Human_swiss_prot_no： Q8NEM0
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8NEM0/entry
Mouse_gene_id： 244329
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244329
Mouse_swiss_prot_no： Q7TT79
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q7TT79
特异性： Microcephalin Polyclonal Antibody detects endogenous levels of Microcephalin protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MCPH1; Microcephalin
实测条带： 93kD
功能： disease:Defects in MCPH1 are a cause of premature chromosome condensation with microcephaly and mental retardation (PCC syndrome) [MIM:606858]. PCC syndrome is a disorder of microcephaly, short stature and misregulated chromosome condensation. Patients with this condition have a high number (10%-15%) of prophase-like cells in routine cytogenetic preparations and have poor-quality metaphase G-banding.,disease:Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.,function:Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.,miscellaneous:MCPH1 deficient cells exhibit a delay in post-mitotic chromosome decondensation.,online information:A grey matter - Issue 64 of November 2005,similarity:Contains 3 BRCT domains.,tissue specificity:Expressed in fetal brain, liver and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
组织表达： Expressed in fetal brain, liver and kidney.
科研货号： PLA016805

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