MEK-1/2 Polyclonal Antibody

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商品货号： PLA016770

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MAP2K1/MAP2K2
蛋白名称： Dual specificity mitogen-activated protein kinase kinase 1/2
Human_gene_id： 5604/5605
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5604
Human_swiss_prot_no： Q02750/P36507
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q02750/entry
Mouse_gene_id： 26395/26396
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26395
Rat_gene_id： 170851/58960
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170851
Rat_swiss_prot_no： Q01986/P36506
Rat_swiss_link： http://www.uniprot.org/uniprot/Q01986
特异性： MEK-1/2 Polyclonal Antibody detects endogenous levels of MEK-1/2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k
实测条带： 43kD
信号通路： Regulates Angiogenesis; Regulation of Actin Dynamics; Stem cell pathway; T_Cell_Receptor; Cell Growth; Insulin Receptor; Toll_Like; MAPK_ERK_Growth;MAPK_G_Protein; ErbB/HER; B_Cell_Antigen; PI3K/Akt
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,enzyme regulation:Activated by phosphorylation.,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.,PTM:Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.,PTM:Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein . Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). .
组织表达： Widely expressed, with extremely low levels in brain.
科研货号： PLA016770

MEK-1/2 Polyclonal Antibody

Catalog No PLA016770

Product information

基因名称： MAP2K1/MAP2K2
蛋白名称： Dual specificity mitogen-activated protein kinase kinase 1/2
Human_gene_id： 5604/5605
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5604
Human_swiss_prot_no： Q02750/P36507
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q02750/entry
Mouse_gene_id： 26395/26396
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26395
Rat_gene_id： 170851/58960
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170851
Rat_swiss_prot_no： Q01986/P36506
Rat_swiss_link： http://www.uniprot.org/uniprot/Q01986
特异性： MEK-1/2 Polyclonal Antibody detects endogenous levels of MEK-1/2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k
实测条带： 43kD
信号通路： Regulates Angiogenesis; Regulation of Actin Dynamics; Stem cell pathway; T_Cell_Receptor; Cell Growth; Insulin Receptor; Toll_Like; MAPK_ERK_Growth;MAPK_G_Protein; ErbB/HER; B_Cell_Antigen; PI3K/Akt
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,enzyme regulation:Activated by phosphorylation.,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.,PTM:Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.,PTM:Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein . Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). .
组织表达： Widely expressed, with extremely low levels in brain.
科研货号： PLA016770

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