其他名称： KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K cha
实测条带： 30kD
信号通路： Vascular smooth muscle contraction;
功能： domain:The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.,function:Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.,PTM:N-glycosylated.,similarity:Belongs to the KCNMB family.,subunit:Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.,tissue specificity:Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Multi-pass membrane protein.
组织表达： Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
其他名称： KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K cha
实测条带： 30kD
信号通路： Vascular smooth muscle contraction;
功能： domain:The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.,function:Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.,PTM:N-glycosylated.,similarity:Belongs to the KCNMB family.,subunit:Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.,tissue specificity:Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Multi-pass membrane protein.
组织表达： Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
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