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MASP-2 Polyclonal Antibody
商品货号: PLA016721
适 应 性: 人,大鼠,小鼠,
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: MASP2
  • 蛋白名称: Mannan-binding lectin serine protease 2
  • Human_gene_id: 10747
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10747
  • Human_swiss_prot_no: O00187
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O00187/entry
  • Mouse_swiss_prot_no: Q91WP0
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q91WP0
  • 特异性: MASP-2 Polyclonal Antibody detects endogenous levels of MASP-2 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MASP2; Mannan-binding lectin serine protease 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2
  • 实测条带: 75kD
  • 信号通路: Complement and coagulation cascades;
  • 功能: catalytic activity:Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).,disease:Genetic variation in MASP2 is the cause of MASP2 deficiency [MIM:605102]. It is associated with susceptibility to infections and with the development of immunologic disease.,function:Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.,miscellaneous:Dimerization and MBL2 binding requires calcium ions.,online information:MASP2 mutation db,PTM:Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1.,tissue specificity:Plasma.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted.
  • 组织表达: Plasma.
  • 科研货号: PLA016721
MASP-2 Polyclonal Antibody
Catalog No PLA016721
Product information
  • 基因名称: MASP2
  • 蛋白名称: Mannan-binding lectin serine protease 2
  • Human_gene_id: 10747
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10747
  • Human_swiss_prot_no: O00187
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O00187/entry
  • Mouse_swiss_prot_no: Q91WP0
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q91WP0
  • 特异性: MASP-2 Polyclonal Antibody detects endogenous levels of MASP-2 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MASP2; Mannan-binding lectin serine protease 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2
  • 实测条带: 75kD
  • 信号通路: Complement and coagulation cascades;
  • 功能: catalytic activity:Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).,disease:Genetic variation in MASP2 is the cause of MASP2 deficiency [MIM:605102]. It is associated with susceptibility to infections and with the development of immunologic disease.,function:Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.,miscellaneous:Dimerization and MBL2 binding requires calcium ions.,online information:MASP2 mutation db,PTM:Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1.,tissue specificity:Plasma.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted.
  • 组织表达: Plasma.
  • 科研货号: PLA016721
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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