其他名称： MAGI2; ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-
实测条带： 156kD
信号通路： Tight junction;
功能： function:Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 2 WW domains.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:Membrane-associated in synaptosomes.,subunit:Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By similarity). Interacts through its guanylate kinase domain with DLGAP1 (By similarity). Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity). Interacts with DDN.,tissue specificity:Specifically expressed in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Late endosome . Cell junction, synapse, synaptosome . Cell membrane ; Peripheral membrane protein . Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). .
组织表达： Specifically expressed in brain.
科研货号： PLA016697
MAGI-2 Polyclonal Antibody
Catalog NoPLA016697
Product information
基因名称： MAGI2
蛋白名称： Membrane-associated guanylate kinase WW and PDZ domain-containing protein 2
其他名称： MAGI2; ACVRINP1; AIP1; KIAA0705; Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 2; Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-
实测条带： 156kD
信号通路： Tight junction;
功能： function:Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 2 WW domains.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:Membrane-associated in synaptosomes.,subunit:Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By similarity). Interacts through its guanylate kinase domain with DLGAP1 (By similarity). Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity). Interacts with DDN.,tissue specificity:Specifically expressed in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Late endosome . Cell junction, synapse, synaptosome . Cell membrane ; Peripheral membrane protein . Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). .
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