其他名称： LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91
实测条带： 80kD
信号通路： Alzheimer's disease;
功能： function:Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.,PTM:Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.,PTM:Phosphorylated on serine and threonine residues.,PTM:Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.,PTM:The N-terminus is blocked.,similarity:Belongs to the LDLR family.,similarity:Contains 22 EGF-like domains.,similarity:Contains 31 LDL-receptor class A domains.,similarity:Contains 34 LDL-receptor class B repeats.,subcellular location:After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.,subunit:Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1.,tissue specificity:Most abundant in liver, brain and lung.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm . Nucleus . After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. .; Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. .
组织表达： Most abundant in liver, brain and lung.
tag： hot
科研货号： PLA016659
LRP1 Polyclonal Antibody
Catalog NoPLA016659
Product information
基因名称： LRP1
蛋白名称： Prolow-density lipoprotein receptor-related protein 1
其他名称： LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91
实测条带： 80kD
信号通路： Alzheimer's disease;
功能： function:Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.,PTM:Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.,PTM:Phosphorylated on serine and threonine residues.,PTM:Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.,PTM:The N-terminus is blocked.,similarity:Belongs to the LDLR family.,similarity:Contains 22 EGF-like domains.,similarity:Contains 31 LDL-receptor class A domains.,similarity:Contains 34 LDL-receptor class B repeats.,subcellular location:After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.,subunit:Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1.,tissue specificity:Most abundant in liver, brain and lung.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm . Nucleus . After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. .; Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. .
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