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LRAT Polyclonal Antibody
商品货号: PLA016657
适 应 性: 人,小鼠,大鼠
WB IHC IF ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: LRAT
  • 蛋白名称: Lecithin retinol acyltransferase
  • Human_gene_id: 9227
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9227
  • Human_swiss_prot_no: O95237
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O95237/entry
  • Mouse_gene_id: 79235
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79235
  • Mouse_swiss_prot_no: Q9JI60
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9JI60
  • Rat_gene_id: 64047
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64047
  • Rat_swiss_prot_no: Q9JI61
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9JI61
  • 特异性: LRAT Polyclonal Antibody detects endogenous levels of LRAT protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: LRAT; Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase
  • 实测条带: 27kD
  • 信号通路: Retinol metabolism;
  • 功能: catalytic activity:Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding-protein].,disease:Defects in LRAT are a cause of severe early-onset retinal dystrophy (RD) [MIM:604863].,enzyme regulation:Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).,function:Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.,induction:LRAT activity is up-regulated by dietary vitamin A. Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the H-rev107 family.,tissue specificity:Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Endoplasmic reticulum membrane ; Single-pass membrane protein . Rough endoplasmic reticulum . Endosome, multivesicular body . Cytoplasm, perinuclear region . Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). .
  • 组织表达: Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.
  • 科研货号: PLA016657
LRAT Polyclonal Antibody
Catalog No PLA016657
Product information
  • 基因名称: LRAT
  • 蛋白名称: Lecithin retinol acyltransferase
  • Human_gene_id: 9227
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9227
  • Human_swiss_prot_no: O95237
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/O95237/entry
  • Mouse_gene_id: 79235
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79235
  • Mouse_swiss_prot_no: Q9JI60
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9JI60
  • Rat_gene_id: 64047
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64047
  • Rat_swiss_prot_no: Q9JI61
  • Rat_swiss_link: http://www.uniprot.org/uniprot/Q9JI61
  • 特异性: LRAT Polyclonal Antibody detects endogenous levels of LRAT protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: LRAT; Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase
  • 实测条带: 27kD
  • 信号通路: Retinol metabolism;
  • 功能: catalytic activity:Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding-protein].,disease:Defects in LRAT are a cause of severe early-onset retinal dystrophy (RD) [MIM:604863].,enzyme regulation:Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).,function:Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.,induction:LRAT activity is up-regulated by dietary vitamin A. Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the H-rev107 family.,tissue specificity:Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Endoplasmic reticulum membrane ; Single-pass membrane protein . Rough endoplasmic reticulum . Endosome, multivesicular body . Cytoplasm, perinuclear region . Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). .
  • 组织表达: Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.
  • 科研货号: PLA016657
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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