LIMK-1/2 Polyclonal Antibody

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商品货号： PLA016639

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： LIMK1/LIMK2
蛋白名称： LIM domain kinase 1/LIM domain kinase 2
Human_gene_id： 3984/3985
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3984
Human_swiss_prot_no： P53667/P53671
Human_swiss_link： http://www.uniprot.org/uniprotkb/P53667/entry
Mouse_gene_id： 16885/16886
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16885
Rat_gene_id： 29524
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29524
Rat_swiss_prot_no： P53669/P53670
Rat_swiss_link： http://www.uniprot.org/uniprot/P53669
特异性： LIMK-1/2 Polyclonal Antibody detects endogenous levels of LIMK-1/2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2
实测条带： 72kD
信号通路： Axon guidance;Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.,PTM:Autophosphorylated.,PTM:Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Self-associates. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with SSH1. Interacts with NISCH.,tissue specificity:Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. .
组织表达： Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
科研货号： PLA016639

LIMK-1/2 Polyclonal Antibody

Catalog No PLA016639

Product information

基因名称： LIMK1/LIMK2
蛋白名称： LIM domain kinase 1/LIM domain kinase 2
Human_gene_id： 3984/3985
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3984
Human_swiss_prot_no： P53667/P53671
Human_swiss_link： http://www.uniprot.org/uniprotkb/P53667/entry
Mouse_gene_id： 16885/16886
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16885
Rat_gene_id： 29524
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29524
Rat_swiss_prot_no： P53669/P53670
Rat_swiss_link： http://www.uniprot.org/uniprot/P53669
特异性： LIMK-1/2 Polyclonal Antibody detects endogenous levels of LIMK-1/2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2
实测条带： 72kD
信号通路： Axon guidance;Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.,PTM:Autophosphorylated.,PTM:Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Self-associates. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with SSH1. Interacts with NISCH.,tissue specificity:Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. .
组织表达： Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
科研货号： PLA016639

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