其他名称： KCNV2; Potassium voltage-gated channel subfamily V member 2; Voltage-gated potassium channel subunit Kv8.2
实测条带： 62kD
功能： disease:Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.,similarity:Belongs to the potassium channel family. V subfamily.,subcellular location:Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.,subunit:Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.,tissue specificity:Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
组织表达： Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.
科研货号： PLA016598
KV8.2 Polyclonal Antibody
Catalog NoPLA016598
Product information
基因名称： KCNV2
蛋白名称： Potassium voltage-gated channel subfamily V member 2
其他名称： KCNV2; Potassium voltage-gated channel subfamily V member 2; Voltage-gated potassium channel subunit Kv8.2
实测条带： 62kD
功能： disease:Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.,similarity:Belongs to the potassium channel family. V subfamily.,subcellular location:Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.,subunit:Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.,tissue specificity:Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Multi-pass membrane protein. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
组织表达： Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.
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