功能： alternative products:Additional isoforms seem to exist,disease:Defects in KCNQ4 are the cause of non-syndromic sensorineural deafness autosomal dominant type 2 (DFNA2A) [MIM:600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors.,miscellaneous:Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.,online information:Gene page,similarity:Belongs to the potassium channel family. KQT subfamily.,subcellular location:Situated at the basal membrane of cochlear outer hair cells.,subunit:May form heteromultimers with KCNQ3.,tissue specificity:Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Basal cell membrane; Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells. .
组织表达： Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
科研货号： PLA016547
KCNQ4 Polyclonal Antibody
Catalog NoPLA016547
Product information
基因名称： KCNQ4
蛋白名称： Potassium voltage-gated channel subfamily KQT member 4
功能： alternative products:Additional isoforms seem to exist,disease:Defects in KCNQ4 are the cause of non-syndromic sensorineural deafness autosomal dominant type 2 (DFNA2A) [MIM:600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors.,miscellaneous:Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.,online information:Gene page,similarity:Belongs to the potassium channel family. KQT subfamily.,subcellular location:Situated at the basal membrane of cochlear outer hair cells.,subunit:May form heteromultimers with KCNQ3.,tissue specificity:Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Basal cell membrane; Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells. .
组织表达： Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
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