Integrin β4 Polyclonal Antibody

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商品货号： PLA016485

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： ITGB4
蛋白名称： Integrin beta-4
Human_gene_id： 3691
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3691
Human_swiss_prot_no： P16144
Human_swiss_link： http://www.uniprot.org/uniprotkb/P16144/entry
Mouse_swiss_prot_no： A2A863
Mouse_swiss_link： http://www.uniprot.org/uniprot/A2A863
Rat_gene_id： 25724
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25724
Rat_swiss_prot_no： Q64632
Rat_swiss_link： http://www.uniprot.org/uniprot/Q64632
特异性： Integrin β4 Polyclonal Antibody detects endogenous levels of Integrin β4 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ITGB4; Integrin beta-4; GP150; CD antigen CD104
实测条带： 202kD
信号通路： Focal adhesion;ECM-receptor interaction;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能： disease:Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.,disease:Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.,domain:The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.,function:Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 Calx-beta domain.,similarity:Contains 1 VWFA domain.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.,tissue specificity:Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
组织表达： Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
科研货号： PLA016485

Integrin β4 Polyclonal Antibody

Catalog No PLA016485

Product information

基因名称： ITGB4
蛋白名称： Integrin beta-4
Human_gene_id： 3691
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3691
Human_swiss_prot_no： P16144
Human_swiss_link： http://www.uniprot.org/uniprotkb/P16144/entry
Mouse_swiss_prot_no： A2A863
Mouse_swiss_link： http://www.uniprot.org/uniprot/A2A863
Rat_gene_id： 25724
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25724
Rat_swiss_prot_no： Q64632
Rat_swiss_link： http://www.uniprot.org/uniprot/Q64632
特异性： Integrin β4 Polyclonal Antibody detects endogenous levels of Integrin β4 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ITGB4; Integrin beta-4; GP150; CD antigen CD104
实测条带： 202kD
信号通路： Focal adhesion;ECM-receptor interaction;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能： disease:Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.,disease:Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.,domain:The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.,function:Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 Calx-beta domain.,similarity:Contains 1 VWFA domain.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.,tissue specificity:Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
组织表达： Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
科研货号： PLA016485

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