其他名称： LILRB4; ILT3; LIR5; Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18;
分子量： 49kD
功能： domain:Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.,induction:Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Ligand binding leads to internalization and translocation to an antigen-processing compartment.,subunit:Binds PTPN6 when phosphorylated.,tissue specificity:Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Ligand binding leads to internalization and translocation to an antigen-processing compartment. .
组织表达： Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.
科研货号： PLA016470
ILT-3 Polyclonal Antibody
Catalog NoPLA016470
Product information
基因名称： LILRB4
蛋白名称： Leukocyte immunoglobulin-like receptor subfamily B member 4
其他名称： LILRB4; ILT3; LIR5; Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18;
分子量： 49kD
功能： domain:Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.,induction:Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Ligand binding leads to internalization and translocation to an antigen-processing compartment.,subunit:Binds PTPN6 when phosphorylated.,tissue specificity:Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Ligand binding leads to internalization and translocation to an antigen-processing compartment. .
组织表达： Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.
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