功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.,induction:Inhibited rather than stimulated by Magnesium.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.,tissue specificity:Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm .
组织表达： Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.,induction:Inhibited rather than stimulated by Magnesium.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.,tissue specificity:Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm .
组织表达： Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
在线咨询
湘公网安备