IFN-γRα Polyclonal Antibody

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商品货号： PLA016422

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： IFNGR1
蛋白名称： Interferon gamma receptor 1
Human_gene_id： 3459
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3459
Human_swiss_prot_no： P15260
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15260/entry
Mouse_gene_id： 15979
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15979
Mouse_swiss_prot_no： P15261
Mouse_swiss_link： http://www.uniprot.org/uniprot/P15261
特异性： IFN-γRα Polyclonal Antibody detects endogenous levels of IFN-γRα protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： IFNGR1; Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD antigen CD119
实测条带： 83kD
信号通路： Cytokine-cytokine receptor interaction;Jak_STAT;Natural killer cell mediated cytotoxicity;
功能： disease:Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.,function:Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.,online information:IFNGR1 mutation db,polymorphism:A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIM:600263].,PTM:Phosphorylated at Ser/Thr residues.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein .
组织表达： Blood,Liver,Prostate,
tag： hot
科研货号： PLA016422

IFN-γRα Polyclonal Antibody

Catalog No PLA016422

Product information

基因名称： IFNGR1
蛋白名称： Interferon gamma receptor 1
Human_gene_id： 3459
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3459
Human_swiss_prot_no： P15260
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15260/entry
Mouse_gene_id： 15979
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15979
Mouse_swiss_prot_no： P15261
Mouse_swiss_link： http://www.uniprot.org/uniprot/P15261
特异性： IFN-γRα Polyclonal Antibody detects endogenous levels of IFN-γRα protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： IFNGR1; Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD antigen CD119
实测条带： 83kD
信号通路： Cytokine-cytokine receptor interaction;Jak_STAT;Natural killer cell mediated cytotoxicity;
功能： disease:Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.,function:Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.,online information:IFNGR1 mutation db,polymorphism:A genetic variation in the IFNGR1 gene is associated with susceptibility to Helicobacter pylori infection [MIM:600263].,PTM:Phosphorylated at Ser/Thr residues.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein .
组织表达： Blood,Liver,Prostate,
tag： hot
科研货号： PLA016422

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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