Frizzled-8 Polyclonal Antibody

> > > >

商品货号： PLA016007

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

在线咨询

MSDS

说明书

商品描述

基因名称： FZD8
蛋白名称： Frizzled-8
Human_gene_id： 8325
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8325
Human_swiss_prot_no： Q9H461
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9H461/entry
Mouse_gene_id： 14370
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14370
Mouse_swiss_prot_no： Q61091
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61091
Rat_gene_id： 1.0091e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100909849
Rat_swiss_prot_no： Q498S8
Rat_swiss_link： http://www.uniprot.org/uniprot/Q498S8
特异性： Frizzled-8 Polyclonal Antibody detects endogenous levels of Frizzled-8 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： FZD8; Frizzled-8; Fz-8; hFz8
实测条带： 70kD
信号通路： WNT;WNT-T CELLMelanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,subunit:Interacts with GOPC. Interacts with RSPO1 and RSPO3.,tissue specificity:Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Multi-pass membrane protein. Golgi apparatus . Cell membrane ; Multi-pass membrane protein . Colocalizes with GOPC at the Golgi apparatus. .
组织表达： Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
科研货号： PLA016007

Frizzled-8 Polyclonal Antibody

Catalog No PLA016007

Product information

基因名称： FZD8
蛋白名称： Frizzled-8
Human_gene_id： 8325
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8325
Human_swiss_prot_no： Q9H461
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9H461/entry
Mouse_gene_id： 14370
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14370
Mouse_swiss_prot_no： Q61091
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61091
Rat_gene_id： 1.0091e+008
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100909849
Rat_swiss_prot_no： Q498S8
Rat_swiss_link： http://www.uniprot.org/uniprot/Q498S8
特异性： Frizzled-8 Polyclonal Antibody detects endogenous levels of Frizzled-8 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： FZD8; Frizzled-8; Fz-8; hFz8
实测条带： 70kD
信号通路： WNT;WNT-T CELLMelanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,subunit:Interacts with GOPC. Interacts with RSPO1 and RSPO3.,tissue specificity:Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane; Multi-pass membrane protein. Golgi apparatus . Cell membrane ; Multi-pass membrane protein . Colocalizes with GOPC at the Golgi apparatus. .
组织表达： Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
科研货号： PLA016007

Hunan UPT Biotechnology Co.,Ltd

Website：www.uptbio.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.