Frizzled-5 Polyclonal Antibody

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商品货号： PLA016003

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： FZD5
蛋白名称： Frizzled-5
Human_gene_id： 7855
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7855
Human_swiss_prot_no： Q13467
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13467/entry
Mouse_gene_id： 14367
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14367
Mouse_swiss_prot_no： Q9EQD0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9EQD0
Rat_gene_id： 317674
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=317674
Rat_swiss_prot_no： Q8CHL0
Rat_swiss_link： http://www.uniprot.org/uniprot/Q8CHL0
特异性： Frizzled-5 Polyclonal Antibody detects endogenous levels of Frizzled-5 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： FZD5; C2orf31; Frizzled-5; Fz-5; hFz5; FzE5
实测条带： 65kD
信号通路： WNT;WNT-T CELLMelanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,subcellular location:Localized at the plasma membrane and also found at the Golgi.,subunit:Interacts with GOPC.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell projection, axon . Localized at the plasma membrane and also found at the Golgi. .
组织表达： Oesophageal carcinoma,Retina,
tag： hot
科研货号： PLA016003

Frizzled-5 Polyclonal Antibody

Catalog No PLA016003

Product information

基因名称： FZD5
蛋白名称： Frizzled-5
Human_gene_id： 7855
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7855
Human_swiss_prot_no： Q13467
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13467/entry
Mouse_gene_id： 14367
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14367
Mouse_swiss_prot_no： Q9EQD0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9EQD0
Rat_gene_id： 317674
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=317674
Rat_swiss_prot_no： Q8CHL0
Rat_swiss_link： http://www.uniprot.org/uniprot/Q8CHL0
特异性： Frizzled-5 Polyclonal Antibody detects endogenous levels of Frizzled-5 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： FZD5; C2orf31; Frizzled-5; Fz-5; hFz5; FzE5
实测条带： 65kD
信号通路： WNT;WNT-T CELLMelanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能： domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,subcellular location:Localized at the plasma membrane and also found at the Golgi.,subunit:Interacts with GOPC.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell projection, axon . Localized at the plasma membrane and also found at the Golgi. .
组织表达： Oesophageal carcinoma,Retina,
tag： hot
科研货号： PLA016003

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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