其他名称： ELOVL4; Elongation of very long chain fatty acids protein 4; 3-keto acyl-CoA synthase ELOVL4; ELOVL fatty acid elongase 4; ELOVL FA elongase 4
实测条带： 37kD
功能： disease:Defects in ELOVL4 are the cause of macular dystrophy autosomal dominant chromosome 6-linked (ADMD) [MIM:600110]. A form of macular degeneration characterized by decreased visual acuity, macular atrophy and extensive fundus flecks.,disease:Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3) [MIM:600110]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Involved in the biosynthesis of very long chain fatty acids. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May be involved in one of these three elongation steps.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the ELO family.,tissue specificity:Expressed in the retina and at much lower level in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.
科研货号： PLA015804
ELOVL4 Polyclonal Antibody
Catalog NoPLA015804
Product information
基因名称： ELOVL4
蛋白名称： Elongation of very long chain fatty acids protein 4
其他名称： ELOVL4; Elongation of very long chain fatty acids protein 4; 3-keto acyl-CoA synthase ELOVL4; ELOVL fatty acid elongase 4; ELOVL FA elongase 4
实测条带： 37kD
功能： disease:Defects in ELOVL4 are the cause of macular dystrophy autosomal dominant chromosome 6-linked (ADMD) [MIM:600110]. A form of macular degeneration characterized by decreased visual acuity, macular atrophy and extensive fundus flecks.,disease:Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3) [MIM:600110]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Involved in the biosynthesis of very long chain fatty acids. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May be involved in one of these three elongation steps.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the ELO family.,tissue specificity:Expressed in the retina and at much lower level in the brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达： Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.
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