eIF2α Polyclonal Antibody

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商品货号： PLA015777

适应性： 人,小鼠,大鼠,猴,鱼

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： EIF2S1
蛋白名称： Eukaryotic translation initiation factor 2 subunit 1
Human_gene_id： 1965
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1965
Human_swiss_prot_no： P05198
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05198/entry
Mouse_gene_id： 13665
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13665
Mouse_swiss_prot_no： Q6ZWX6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6ZWX6
Rat_gene_id： 54318
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54318
Rat_swiss_prot_no： P68101
Rat_swiss_link： http://www.uniprot.org/uniprot/P68101
特异性： eIF2α Polyclonal Antibody detects endogenous levels of eIF2α protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha
实测条带： 38kD
功能： function:Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.,PTM:Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A, eIF2S1 phosphorylation state is modulated.,similarity:Belongs to the eIF-2-alpha family.,similarity:Contains 1 S1 motif domain.,subunit:Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, Stress granule . Colocalizes with NANOS3 in the stress granules. .
组织表达： B cells,Brain,Fibroblast,Placenta,
tag： hot
科研货号： PLA015777

eIF2α Polyclonal Antibody

Catalog No PLA015777

Product information

基因名称： EIF2S1
蛋白名称： Eukaryotic translation initiation factor 2 subunit 1
Human_gene_id： 1965
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1965
Human_swiss_prot_no： P05198
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05198/entry
Mouse_gene_id： 13665
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13665
Mouse_swiss_prot_no： Q6ZWX6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6ZWX6
Rat_gene_id： 54318
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54318
Rat_swiss_prot_no： P68101
Rat_swiss_link： http://www.uniprot.org/uniprot/P68101
特异性： eIF2α Polyclonal Antibody detects endogenous levels of eIF2α protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha
实测条带： 38kD
功能： function:Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.,PTM:Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A, eIF2S1 phosphorylation state is modulated.,similarity:Belongs to the eIF-2-alpha family.,similarity:Contains 1 S1 motif domain.,subunit:Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, Stress granule . Colocalizes with NANOS3 in the stress granules. .
组织表达： B cells,Brain,Fibroblast,Placenta,
tag： hot
科研货号： PLA015777

Hunan UPT Biotechnology Co.,Ltd

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