Dok-3 Polyclonal Antibody

> > > >

商品货号： PLA015690

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

在线咨询

MSDS

说明书

商品描述

基因名称： DOK3
蛋白名称： Docking protein 3
Human_gene_id： 79930
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79930
Human_swiss_prot_no： Q7L591
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q7L591/entry
Mouse_gene_id： 27261
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27261
Mouse_swiss_prot_no： Q9QZK7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QZK7
特异性： Dok-3 Polyclonal Antibody detects endogenous levels of Dok-3 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： DOK3; Docking protein 3; Downstream of tyrosine kinase 3
实测条带： 58kD
信号通路： B_Cell_Antigen
功能： domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function.,PTM:Constitutively tyrosine-phosphorylated.,PTM:On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP.,tissue specificity:Expressed in spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
组织表达： Expressed in spleen.
科研货号： PLA015690

Dok-3 Polyclonal Antibody

Catalog No PLA015690

Product information

基因名称： DOK3
蛋白名称： Docking protein 3
Human_gene_id： 79930
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79930
Human_swiss_prot_no： Q7L591
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q7L591/entry
Mouse_gene_id： 27261
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27261
Mouse_swiss_prot_no： Q9QZK7
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QZK7
特异性： Dok-3 Polyclonal Antibody detects endogenous levels of Dok-3 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： DOK3; Docking protein 3; Downstream of tyrosine kinase 3
实测条带： 58kD
信号通路： B_Cell_Antigen
功能： domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function.,PTM:Constitutively tyrosine-phosphorylated.,PTM:On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.,similarity:Belongs to the DOK family. Type A subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP.,tissue specificity:Expressed in spleen.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
组织表达： Expressed in spleen.
科研货号： PLA015690

Hunan UPT Biotechnology Co.,Ltd

Website：www.uptbio.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.