Cytokeratin 18 Polyclonal Antibody

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商品货号： PLA015573

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： KRT18
蛋白名称： Keratin type I cytoskeletal 18
Human_gene_id： 3875
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3875
Human_swiss_prot_no： P05783
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05783/entry
Mouse_gene_id： 16668
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16668
Mouse_swiss_prot_no： P05784
Mouse_swiss_link： http://www.uniprot.org/uniprot/P05784
Rat_gene_id： 294853
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294853
Rat_swiss_prot_no： Q5BJY9
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5BJY9
特异性： Cytokeratin 18 Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： KRT18; CYK18; PIG46; Keratin; type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
实测条带： 47kD
信号通路： Pathogenic Escherichia coli infection;
功能： disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.,tissue specificity:Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Nucleus, nucleolus.
组织表达： Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
tag： hot
科研货号： PLA015573

Cytokeratin 18 Polyclonal Antibody

Catalog No PLA015573

Product information

基因名称： KRT18
蛋白名称： Keratin type I cytoskeletal 18
Human_gene_id： 3875
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3875
Human_swiss_prot_no： P05783
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05783/entry
Mouse_gene_id： 16668
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16668
Mouse_swiss_prot_no： P05784
Mouse_swiss_link： http://www.uniprot.org/uniprot/P05784
Rat_gene_id： 294853
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294853
Rat_swiss_prot_no： Q5BJY9
Rat_swiss_link： http://www.uniprot.org/uniprot/Q5BJY9
特异性： Cytokeratin 18 Polyclonal Antibody detects endogenous levels of Cytokeratin 18 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： KRT18; CYK18; PIG46; Keratin; type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18
实测条带： 47kD
信号通路： Pathogenic Escherichia coli infection;
功能： disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.,tissue specificity:Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, perinuclear region. Nucleus, nucleolus.
组织表达： Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
tag： hot
科研货号： PLA015573

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