Cytokeratin 10 Polyclonal Antibody

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商品货号： PLA015567

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： KRT10
蛋白名称： Keratin type I cytoskeletal 10
Human_gene_id： 3858
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3858
Human_swiss_prot_no： P13645
Human_swiss_link： http://www.uniprot.org/uniprotkb/P13645/entry
Mouse_gene_id： 16661
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16661
Mouse_swiss_prot_no： P02535
Mouse_swiss_link： http://www.uniprot.org/uniprot/P02535
Rat_gene_id： 450225
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=450225
Rat_swiss_prot_no： Q6IFW6
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6IFW6
特异性： Cytokeratin 10 Polyclonal Antibody detects endogenous levels of Cytokeratin 10 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： KRT10; KPP; Keratin; type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10
实测条带： 59kD
功能： disease:Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.,disease:Defects in KRT10 are a cause of epidermal nevus epidermolytic hyperkeratotic type [MIM:600648]. Epidermal nevi affect about 1 in 1,000 people. They appear at or shortly after birth as localized lines of epidermal thickening. The extent of skin involvement varies widely.,disease:Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-10 entry,polymorphism:A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.,tissue specificity:Seen in all suprabasal cell layers including stratum corneum.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space . Cell surface . Localized on the surface of desquamated nasal epithelial cells (PubMed:12427098). Localized on the surface of lung cell lines (PubMed:19627498). .
组织表达： Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498).
科研货号： PLA015567

Cytokeratin 10 Polyclonal Antibody

Catalog No PLA015567

Product information

基因名称： KRT10
蛋白名称： Keratin type I cytoskeletal 10
Human_gene_id： 3858
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3858
Human_swiss_prot_no： P13645
Human_swiss_link： http://www.uniprot.org/uniprotkb/P13645/entry
Mouse_gene_id： 16661
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16661
Mouse_swiss_prot_no： P02535
Mouse_swiss_link： http://www.uniprot.org/uniprot/P02535
Rat_gene_id： 450225
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=450225
Rat_swiss_prot_no： Q6IFW6
Rat_swiss_link： http://www.uniprot.org/uniprot/Q6IFW6
特异性： Cytokeratin 10 Polyclonal Antibody detects endogenous levels of Cytokeratin 10 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： KRT10; KPP; Keratin; type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10
实测条带： 59kD
功能： disease:Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.,disease:Defects in KRT10 are a cause of epidermal nevus epidermolytic hyperkeratotic type [MIM:600648]. Epidermal nevi affect about 1 in 1,000 people. They appear at or shortly after birth as localized lines of epidermal thickening. The extent of skin involvement varies widely.,disease:Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-10 entry,polymorphism:A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.,tissue specificity:Seen in all suprabasal cell layers including stratum corneum.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Secreted, extracellular space . Cell surface . Localized on the surface of desquamated nasal epithelial cells (PubMed:12427098). Localized on the surface of lung cell lines (PubMed:19627498). .
组织表达： Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498).
科研货号： PLA015567

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