信号通路： Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;Drug metabolism;
功能： alternative products:Additional isoforms seem to exist,catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Exhibits low testosterone 6-beta-hydroxylase activity.,induction:By rifampicin.,online information:CYP3A43 alleles,polymorphism:At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.,
信号通路： Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;Drug metabolism;
功能： alternative products:Additional isoforms seem to exist,catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Exhibits low testosterone 6-beta-hydroxylase activity.,induction:By rifampicin.,online information:CYP3A43 alleles,polymorphism:At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.,
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