信号通路： Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;Drug metabolism;
功能： catalytic activity:Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.,catalytic activity:Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.,catalytic activity:Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.,catalytic activity:Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.,induction:By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP3A4 alleles,online information:CYP3A4 entry,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Expressed in prostate and liver.,
组织表达： Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
信号通路： Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;Drug metabolism;
功能： catalytic activity:Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.,catalytic activity:Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.,catalytic activity:Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.,catalytic activity:Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.,induction:By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP3A4 alleles,online information:CYP3A4 entry,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Expressed in prostate and liver.,
组织表达： Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
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