信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Pathways in cancer;Prostate cancer;Small cell lung cancer;
功能： function:Essential for the control of the cell cycle at the late G1 and early S phase.,induction:Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.,PTM:Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,tissue specificity:According to PubMed:9858585: highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943: highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Pathways in cancer;Prostate cancer;Small cell lung cancer;
功能： function:Essential for the control of the cell cycle at the late G1 and early S phase.,induction:Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.,PTM:Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,tissue specificity:According to PubMed:9858585: highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943: highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
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