功能: developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.,function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of frame.,subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole.,subunit:Interacts with LYST.,tissue specificity:Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Centriole-associated, asymmetrically localizes to the daughter centriole.
组织表达: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
功能: developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.,function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of frame.,subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole.,subunit:Interacts with LYST.,tissue specificity:Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Centriole-associated, asymmetrically localizes to the daughter centriole.
组织表达: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.