Cdk1/Cdc2 Polyclonal Antibody

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商品货号： PLA015195

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： CDK1
蛋白名称： Cyclin-dependent kinase 1
Human_gene_id： 983
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=983
Human_swiss_prot_no： P06493
Human_swiss_link： http://www.uniprot.org/uniprotkb/P06493/entry
Mouse_gene_id： 12534
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12534
Mouse_swiss_prot_no： P11440
Mouse_swiss_link： http://www.uniprot.org/uniprot/P11440
Rat_gene_id： 54237
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54237
Rat_swiss_prot_no： P39951
Rat_swiss_link： http://www.uniprot.org/uniprot/P39951
特异性： Cdk1/Cdc2 Polyclonal Antibody detects endogenous levels of Cdk1/Cdc2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase
实测条带： 34kD
信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Gap junction;Progesterone-mediated oocyte maturation;
功能： catalytic activity:ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.,function:Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLGAP5. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
组织表达： Isoform 2 is found in breast cancer tissues.
科研货号： PLA015195

Cdk1/Cdc2 Polyclonal Antibody

Catalog No PLA015195

Product information

基因名称： CDK1
蛋白名称： Cyclin-dependent kinase 1
Human_gene_id： 983
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=983
Human_swiss_prot_no： P06493
Human_swiss_link： http://www.uniprot.org/uniprotkb/P06493/entry
Mouse_gene_id： 12534
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12534
Mouse_swiss_prot_no： P11440
Mouse_swiss_link： http://www.uniprot.org/uniprot/P11440
Rat_gene_id： 54237
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54237
Rat_swiss_prot_no： P39951
Rat_swiss_link： http://www.uniprot.org/uniprot/P39951
特异性： Cdk1/Cdc2 Polyclonal Antibody detects endogenous levels of Cdk1/Cdc2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase
实测条带： 34kD
信号通路： Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Gap junction;Progesterone-mediated oocyte maturation;
功能： catalytic activity:ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.,function:Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLGAP5. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
组织表达： Isoform 2 is found in breast cancer tissues.
科研货号： PLA015195

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